Process for the preparation of 4r-amino-1t-phenyl-1c-ethoxycarbo

Details Process for the preparation of 4r-amino-1t-phenyl-1c-ethoxycarbo Process for the preparation of 4r-amino-1t-phenyl-1c-ethoxycarbo

1974-11-29

1977-02-15

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268R, 260268PH, 26029381, 260471A, C07C10138, C07D29514

Patent

active

040082334

ABSTRACT:
This invention relates to 4r-amino-1t-phenyl-1c-ethoxycarbonyl-cyclohexenes-(2) of formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are hydrogen or alkyl having 1 to 4 carbon atoms, or one of the two groups is allyl, phenalkyl having 7 to 9 carbon atoms or .alpha.-methyl-.beta.-hydroxyethyl; or R.sub.1 and R.sub.2 together form a morpholino group, piperazino group substituted at the 4- position by methyl, benzyl, phenyl, 3-chlorophenyl, 4-chlorophenyl, 2-phenethyl or benzoyl, or a piperidino group substituted at the 4- position by hydroxyl, phenyl, 2-methoxyphenyl, 4-methoxyphenyl, methyl or benzyl and medically acceptable addition compounds derived from inorganic and organic acids or lower alkyl halides. The compounds of the present invention are prepared by separation of 4-amino-1-phenyl-1-ethoxycarbonyl-cyclohexenes-(2), described in U.S. Patent Application Ser. No. 226,509, filed Feb. 15, 1972, into the two possible geometrical isomers. The instant compounds, the 4r-amino-1t-phenyl-1c-ethoxycarbonyl-cyclohexenes-(2) of formula I, exhibit marked analgesic and neuroleptic activities and are useful for the alleviation and reduction of pain.

REFERENCES:
patent: 3557127 (1971-01-01), Satzinger et al.
patent: 3679732 (1972-07-01), Novack

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