Process for preparing 3-methyl-3-cephem antibiotics

Details Process for preparing 3-methyl-3-cephem antibiotics Process for preparing 3-methyl-3-cephem antibiotics

1975-07-14

1977-02-15

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50102

Patent

active

040082288

ABSTRACT:
7-Acylamino-3-methyl-3-cephem-4-carboxylic acids and esters are prepared via the reductive cleavage of a 3-thio substituted 2-cephem-4-carboxylic acid or ester with hydrogen and Raney nickel or zinc in formic acid and DMF to provide reduction product mixtures of the corresponding 7-substituted 3-methyl-2-cephem-4-acid or ester (I) and 3-exomethylenecepham-4-acid or ester (II). Reduction product mixtures are separable via chromatography and individual I and II are isomerized to 3-methyl-3-cephem antibiotics.

REFERENCES:
patent: 3932393 (1976-01-01), Chaunette

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