Process for .omega.-amino-2-hydroxyalkyl derivatives of aminogly

Details Process for .omega.-amino-2-hydroxyalkyl derivatives of aminogly Process for .omega.-amino-2-hydroxyalkyl derivatives of aminogly

1977-02-10

1978-08-15

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

536 4, 536 10, 536 17, 260307C, C07D26324, C07D26506

Patent

active

041074351

ABSTRACT:
1-N-(.omega.-Amino-2-hydroxyalkyl) derivatives of aminoglycoside antibiotics are prepared by reductive alkylation of the parent antibiotic, or a partially protected derivative thereof, with a 6-dihydroxymethyltetrahydro-1, 3-oxazin-2-one or 5-dihydroxymethyloxazolidin-2-one, followed by hydrolysis, and, if necessary, followed by removal of any remaining protecting groups. The products of the process of this invention are known antibacterial agents.

REFERENCES:
patent: 2399118 (1946-04-01), Homeyer
Skulsi et al., Chemical Abstracts, vol. 51, cols. 371 to 372 (1957).

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