Bis-tetrazoylmethyl substituted cephalosporin antibiotics

Details Bis-tetrazoylmethyl substituted cephalosporin antibiotics Bis-tetrazoylmethyl substituted cephalosporin antibiotics

1980-09-17

1982-08-24

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 26, 544 27, 544 21, A61K 31545, C07D50156

Patent

active

043460763

ABSTRACT:
7.beta.-Acylamino-3-cephem-4-carboxylic acids substituted in the 3-position with a bis-tetrazolemethylthiomethyl group and the corresponding 7.alpha.-methoxy cephalosporins represented by the formula ##STR1## wherein R is an acyl group, R.sub.2 is H or OCH.sub.3 and R.sub.4 is H or C.sub.1 -C.sub.3 alkyl; are broad spectrum antibiotics useful in the treatment and control of microorganisms pathogenic to man and animals. 7.beta.-Amino nucleus compounds represented when R is hydrogen are intermediates useful in the preparation of the antibiotics where R is acyl.

REFERENCES:
patent: 4080498 (1978-03-01), Numata et al.
patent: 4100346 (1978-07-01), Gottstein et al.
patent: 4109085 (1978-08-01), Barth
patent: 4113942 (1978-09-01), Barth
patent: 4121040 (1978-10-01), Barth
patent: 4129732 (1978-12-01), Barth
patent: 4286089 (1981-08-01), Berges
patent: 4288436 (1981-09-01), Takaya et al.
H. Faubl. Tetrahedron Letters No. 6, pp. 491-494, Permagon Press Ltd., 1979.

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