Synthesis of ochratoxins

Details Synthesis of ochratoxins Synthesis of ochratoxins

1981-03-19

1982-08-24

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 67, C07D31176

Patent

active

043460399

ABSTRACT:
A simple, direct synthesis route is provided for Ochratoxin compounds, particularly Ochratoxin A, Ochratoxin B, and Ochratoxin C. The reaction involves treating the dimethyl ester of 2-hydroxy-4-methylbenzene-1,3-dioic acid with a deprotonating agent, followed by addition of acetaldehyde, to provide a precursor compound, which can conveniently be converted to Ochratoxins A, B or C. The synthesis route allows for the first time laboratory and industrial scale synthesis of ochratoxins A, B and C in large quantities and pure form making them available as toxins, for use as anti-toxin investigation works, and for biological activity investigations and residue studies.

REFERENCES:
Kraus, Chem. Abst., 94:47077m.
Steyn et al., Tetrahedron, vol. 23, pp. 4449-4461, 1967.
Roberts et al., J. Chem. Soc., (C), 1970, p. 278.

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