Prostanoic acid derivatives and their preparation

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260410, 260456R, 260464, 556441, 549 69, 546309, 542426, 549480, 549416, 549419, 549420, 560106, 560148, 560162, 560231, 560 32, 564 91, 564 98, 564171, 564177, 564186, 564189, 424275, 424283, 424285, 424300, 424308, 424311, 424312, 424320, 424321, 424324, C07C17700, A61K 31557

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active

043594670

ABSTRACT:
Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is an acid, ester, amide or hydroxyalkylene group; R.sub.2 and R.sub.3 are H or alkyl; R.sub.4 and R.sub.5 are both CH.sub.3 or one is Cl and the other is CH.sub.3 ; A is CH.sub.2 CH.sub.2 or --CH.dbd.CH; B is CH.sub.2 CH.sub.2, trans- ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH.dbd.CH--, R.sub.12 being H, CH.sub.3, CN or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R.sub.1 is an acid group, possess pharmacological activity, including abortion triggering activity.

REFERENCES:
patent: 3919285 (1975-11-01), Axen
patent: 3932479 (1976-01-01), Bernady
patent: 4064351 (1977-12-01), Sakai
patent: 4220798 (1980-09-01), Scolastico

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