Process for making an octapeptide useful for the treatment of di

Details Process for making an octapeptide useful for the treatment of di Process for making an octapeptide useful for the treatment of di

1975-12-29

1978-08-15

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601127, 424177, 424178, C07C10352, A61K 3700

Patent

active

041071581

ABSTRACT:
Process for the preparation of the compound consisting of the peptide chain: leucyl -- seryl -- arginyl -- leucyl -- phenylalanyl -- aspartyl -- asparaginyl -- alanine (I), characterized in that the synthesis is carried out from constituent amino-acids of the peptide chain (I), or from peptide elements resulting from the condensation of two or several of these basic amino-acids, and by the condensation of these amino-acids or peptide elements, in a succession of steps so that the basic amino-acids occur in the final peptide chain in the order indicated in (I).

REFERENCES:
patent: 3928306 (1975-12-01), Uchijama et al.
patent: 3953415 (1976-04-01), Kisfaludy et al.
patent: 3978035 (1976-08-01), Wunsch et al.
E. Schroder and K. Lubke, "The Peptides," vol. 1, Academic Press, New York, 1965, pp. 1-2.
J. M. Stewart and J. D. Young, "Solid Phase Peptide Synthesis," W. H. Freeman & Co., San Francisco, 1969, pp. 3-5.

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