Method of delivering a therapeutic agent to a target capillary b

Details Method of delivering a therapeutic agent to a target capillary b Method of delivering a therapeutic agent to a target capillary b

1980-06-27

1982-08-24

Howell, Kyle L.

Surgery

Truss

Perineal

128260, 252 6253, A61K 950, A61K 938

Patent

active

043455883

ABSTRACT:
Intravascularly-administrable, magnetically-localizable biodegradable microspheres containing a therapeutic agent, such as an oncolytic agent, are prepared and administered so that they can be permanently localized in a target capillary bed for release of the therapeutic agent therein. The effects of the therapeutic agent can thereby be relatively confined to the area of the capillary bed. Of particular importance is the administration of oncolytic agents by the method, since this permits the undesirable side effects of the oncolytic agents to be substantially reduced, while at the same time increasing the anti-cancer effectiveness of the drug.

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patent: 4269826 (1981-05-01), Zimmermann et al.
Merck Index, entry 202.
Proceedings Nat'l. Academy of Science, vol. 72, No. 3, pp. 937-940, Mar. 1973, paper by Hahn, Braun et al.
Freeman et al., J. Appl. Physics., Suppl., vol. 31, No. 5, 4045-4055, (May, 1960).
Meyers et al., Amer. J. Roentg., 90, 1068-1077, (Nov. 1963).
Takai et al., Chem. Abs., vol. 80, No. 5, p. 293, Abstract 52392a, (1974).

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