Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-07-08
1985-09-10
Torrence, Dolph H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
260465D, 546174, 548375, 548378, 548495, 548503, 549 77, 549496, 560 38, 560 39, C07D21170, C07C10102, C07C12178
Patent
active
045407916
ABSTRACT:
A process for producing a compound of the formula ##STR1## wherein A is aryl or alkyl, R.sub.1 is an aromatic radical and R.sub.2 is hydrogen, alkyl, aryl, cyano, --COOalkyl or --COOaryl, which process comprises reacting 1 mol of an aromatic nitrile of the formula R.sub.1 --CN (II) with 1 mol of an acetic ester of the formula (X)(R.sub.2)CH--COOA (III) in which X is halogen, in the presence of zinc, in an inert organic solvent and at a temperature of less than 80.degree. C.; hydrolyzing in an alkaline medium the formed reaction product; and then isolating the compound of the formula I.
The compounds of the formula I are valuable intermediates for producing heterocyclic compounds.
REFERENCES:
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E. Santaniello et al., Synthesis, 1977, 698.
T. Iimori et al., Tetrahedron Letters, 27, 2525, (1979).
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R. K. Howe et al., J. Heterocyclic Chem., 15, 1001, (1978).
T. Hiyama et al., Tetrahedron Letters, 23, 1597, (1982).
Cassar Luigi
Iqbal Abul
Rochat Alain C.
Ciba-Geigy Corporation
Hall Luther A. R.
Torrence Dolph H.
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