Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-10-13
1985-09-10
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549466, A61K 3134
Patent
active
045407096
ABSTRACT:
5-allyl-2-(3,4-dimethoxyphenyl)-3a,.alpha.-methoxy-3-methyl-2,3,3a,6-tetrah ydro-6-oxobenzofuran and analogs thereof as PAF-antagonists have been isolated from Piper futokadsura Sieb. et Zucc. and its analogs prepared. These neolignan compounds are found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and are thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, and adult respiratory distress syndrome.
REFERENCES:
Iida et al., I, Phytochemistry, Dec. 1982, 21(12), pp. 2939-2941.
Iida et al., II , Phytochemistry, Mar. 1982, 22(3), pp. 763-766.
K. Matsui et al., Agr. Biol. Chem., 40, 1045 (1976).
K. Matsui et al., Agr. Biol. Chem., 40,1113 (1976).
Chang Michael N.
Hwang San-Bao
Cheng Theresa Y.
Dentz Bernard I.
Jiles Henry R.
Merck & Co. , Inc.
Monaco Mario A.
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