Tetrazole derivatives, anti-ulcer composition containing the sam

Details Tetrazole derivatives, anti-ulcer composition containing the sam Tetrazole derivatives, anti-ulcer composition containing the sam

1981-12-23

1985-09-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548251, 548200, 548215, 548240, 548276, 548253, 544333, 544 63, 544132, 546238, 546276, 546210, A61K 3141, C07D25704

Patent

active

045407037

ABSTRACT:
Tetrazole derivatives of the formula: ##STR1## wherein R.sup.1 is an optional defined substituent; A is sulfur or a lower alkylene-thio; l is 0 or 1; B is a lower alkylene; R.sup.2 is hydroxy, a lower alkoxy, or a group: ##STR2## wherein R.sup.3 and R.sup.4 are optional defined substituents, or the R.sup.3 and R.sup.4 may combine together with the nitrogen atom to which they are joined to form a defined heterocyclic group, and a pharmaceutically acceptable salt thereof, which have prophylactic or therapeutic activities against peptic and/or duodenal ulcers and also anti-inflammatory activity and are useful as an anti-ulcer or anti-inflammatory drug; processes for the preparation of the tetrazole derivatives; and pharmaceutical composition containing said tetrazole derivatives.

REFERENCES:
patent: 3473646 (1973-07-01), Buckler
patent: 4372953 (1983-02-01), Uchida et al.
Jacobson, J. Org. Chem., 18, 1183-1189, 1953.
Jacobson, J. Org. Chem., 21, 311-315, 1956.
La Forge, J. Org. Chem., 21, 767-771, 1956.

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