Spiroketals and process for preparing same

Details Spiroketals and process for preparing same Spiroketals and process for preparing same

1985-07-22

1987-07-14

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549454, 560 9, 560 20, 560 23, 560 55, 560 95, 560 96, 560262, 560264, 568392, C07D30910, C07D30930

Patent

active

046804196

ABSTRACT:
This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 3984564 (1976-10-01), Aoki et al.
patent: 3992551 (1976-11-01), Aoki et al.
patent: 4093629 (1978-06-01), Fisher
patent: 4144352 (1979-03-01), Putter
patent: 4408059 (1983-10-01), Smith et al.
Fisher, M. H. and Mrozik, H., The Avermectin Family of Macrolide-Like Antibiotics, pp. 553-606, "Macrolide Antibiotics: Chemistry, Biology, and Practice", ed. S. Moura, Academic Press, (1984).
Tetrahedron Lett., No. 10, pp. 711-714, (1975).
Journal of Antibiotics, vol. 29, No. 6, Jun. 1976, pp. 76-35 to 76-42 and 76-14 to 76-16.
Burg, R. W., et al, "Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation", Antimicrobial Agents and Chemotherapy, vol. 15, No. 3, Mar. 1979, pp. 361-367.
Takiguchi, Y. et al, "Milbemycins*, A New Family of Macrolide Antibiotics: Fermentation, Isolation and Physico-Chemical Properties", Journal of Antibiotics, vol. 33, No. 10, Oct. 1980, pp. 1120-1127.
Williams, D. R. et al, "Total Synthesis of Mulbemycin .beta..sub.3 ", J. Am. Chem. Soc., 104, pp. 4708-4710, (1982).
Smith, A. B. III et al, "Total Synthesis of Milbemycin .beta..sub.3 ", J. Am. Chem. Soc., 104, pp. 4015-4018, (1982).
Mori, K. et al, "Synthesis of Three Steroisomeric Forms of 2,8-Dimethyl-1,7-dioxaspiro[5,5]undecane, The Main Component of the Cephalic Secretion of Andrena Wilkella", Tetrehedron, 37, pp. 3221-3225.
Mori, K. et al, "Synthesis of Three Steroisomeric Forms of 2,8-Dimethyl-1,7-dioxaspiro[5,5]undecane, The Main Component of the Cephalic Secretion of Andrena Wilkella", Heterocycles, vol. 15, 1981, pp. 1171-1174.
Nakahara Y. et al, "Synthetic Studies of Antibiotic A23187, I. Chiral Synthons for C9-C13 and C14-C20", Tetrehedron Lett., 1981, pp. 3197-3200.
Evans, D. A. et al, "Studies Directed Towards the Total Synthesis of the Ionophore Antibiotic A-23187", Tetrehedron Lett., 1978, pp. 727-730.
Cresp T. M. et al, "An Approach to the Synthesis of Ionphores Related to A23187", Tetrehdron Lett., 1978, pp. 3955-3958.
Baker, R. et al, "The Chemistry of Spiroketals. Enantiospecific Synthesis of the Spiroketal Units of Avermectins B.sub.1b and B.sub.2b ", J. Chem. Soc., Chem. Commun., pp. 309-311, (1985).
Hanessian, et al, "Sterocontrolled Synthesis of the Spiroketal Unit of Avermectin B.sub.1a Agylone", J. Org. Chem., vol. 48, pp. 4427-4430, (1083).
Godoy, J. et al, "Synthesis of the Spiroketal Unit Related to the Avermectins and Milbemycins", J. Chem. Soc., Chem. Commun., pp. 1381-1382, (1084).
Kocienski, P. et al, "A Synthesis of the Spiroketal Moiety of Milbemycin .beta..sub.3 ", J. Chem. Soc., Chem. Commun., pp. 571-573, (1984).
Williams, D. R. et al, "Synthetic Studies of 1,7-dioxaspiro[5.5]undecan-4-ones", Tetrehedron Lett., vol. 24, No. 5, pp. 427-430, (1983).
Kocienski, P. et al, "A New Synthesis of 1,7-dioxaspiro[5.5]undecanes. Applications to a Rectal Gland Secretion of the Olive Fruit Fly (Dacus oleae)", Tetrehdron Lett., vol. 24, No. 36, pp. 3905-3906, (1983).
Kay, I. T. et al, "Spiroketals: The Synthesis of an Olive Fly Pheromone Component, 4-hydroxy-1,7-Dioxaspiro[5,5]undecane, via a Novel Cation-Olefin Cyclisation Step", Tetrehdron Lett., vol. 24, No. 52, pp. 5915-5918.
Kocienski P. et al, "A Synthesis of TalaromycinB", J. Chem. Soc., Chem. Commun., pp. 151-152, (1984).
Heathcock, C. H. et al, "Acyclic Steroselection-13. "Aryl Esters: Reagents for Threo-Aldolization", Tetrehderon, 37, pp. 4087-4095, (1981).
Heathcock, C. H. et al, "Acyclic Steroselection. 11. Double Stereodifferentiation as a Method for Achieving Superior Cram's Rule Selectivity in Aldol Condensation with Chiral Aldehydes", J. Org. Chem., 46, pp. 1296-1309, (1981).
Corey, E. J. et al, "Stereospecific Total Synthesis of Prostaglandins E.sub.3 and F.sub.3a ", J. Amer. Chem. Soc., 93, pp. 1490-1493, (1971).
Fieser, L. F. et al, Reagents for Organic Synthesis, John Wiley & Sons, N.Y., N.Y., pp. 656-659, (1967).

Affiliated with

Also associated with

Rating

Spiroketals and process for preparing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiroketals and process for preparing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiroketals and process for preparing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1428778