Novel benzylalcohols and pharmaceutical compositions and use the

Details Novel benzylalcohols and pharmaceutical compositions and use the Novel benzylalcohols and pharmaceutical compositions and use the

1978-05-18

1980-08-19

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2605706, A61K 31135, C07C 9116, C07C 9122, C07C 9134

Patent

active

042184797

ABSTRACT:
Racemic or optically active .alpha.-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylalcohol [I] may be prepared by condensing 2,3,4-trimethoxyphenethylamine with 2-benzyloxyphenylglyoxal or its hydrate, reducing the resultant .alpha.(2,3,4-tri-methoxyphenethylimino)-2-benzyloxyacetophenone to give .alpha.(2,3,4-trimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol, if required, resolving the 2-benzyloxybenzylalcohol derivative into each of its optically active enantiomers, and subjecting the racemic modification or optically active enantiomer of said 2-benzyloxybenzylalcohol derivative to catalytic hydrogenation. The compound [I] and pharmaceutically acceptable acid addition salts thereof are useful as anti-diabetic agents. They may be also used in the treatment of thrombosis.

REFERENCES:
patent: 3869474 (1975-03-01), Miura et al.
patent: 3952021 (1976-04-01), Ikezaki et al.
patent: 4032575 (1977-06-01), Ikezaki et al.
patent: 4072759 (1978-02-01), Ikezaki et al.
patent: 4131686 (1978-12-01), Ikezaki et al.

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