Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1986-02-03
1987-07-14
Sneed, Helen M. S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
556114, 514492, 514494, 514495, 514496, 514500, 514501, 514503, 514505, A01N 5502, A61K 3130
Patent
active
046803092
ABSTRACT:
A method of treating inflammation or arthritis with metal complexes that can traverse skin and animal cell membranes intact and effectively deliver and release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property enables the metal complexes to release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes can be effectively administered either topically or subcutaneously. Upon topical application, the metal complexes are dispersed in a vehicle to provide a buffered composition to neutralize the initial acidic layer of the skin. These unique and advantageous properties permit the metal complexes to be incorporated into vehicles with an adjusted pH minimizing premature release of the metal ions prior to reaching the targeted inflammatory or arthritic areas. Further, the metal complexes can be dispersed in a greaseless cold cream vehicle formulated to avoid or minimize undesirable chemical incompatibilities. An example of a topical composition employed is disodiummonocopper(II) citrate in an amount of about 10% w/w in a water-dispersible cream base vehicle comprising an oil-in-water emulsion having a pH of about 7.0.
REFERENCES:
patent: 4055655 (1977-10-01), Maurer et al.
patent: 4129509 (1978-12-01), Shringarpurey et al.
patent: 4180473 (1979-12-01), Maurer et al.
patent: 4221785 (1980-09-01), Sorenson
patent: 4278610 (1981-07-01), Maurer et al.
patent: 4287190 (1981-09-01), Boettcher et al.
patent: 4373953 (1983-02-01), Deinet et al.
Sorenson, J of Medicinal Chem., V. 19, No. 1, pp. 135-148 (1976).
Sorenson, Inflammation, 1976, vol. 1, No. 3, pp. 317-331.
Chemical Abstracts, 84, 38591r (1976).
Chemical Abstracts 85, 116777t (1976).
Katz, Rheumatic Diseases Diagnosis and Management, J. B. Lippincott Co., Phila., Toronto, pp. 27-29 (1977).
Whitehouse, M. W. and Walter, W. R.: The Copper Bracelet for Arthritis, Med. J. Australia, (1):938, (Jun. 18, 1977).
Sorenson, J. R. J.: Development of Copper Complexes for Potential Therapeutic Use, Agents and Actions, vol. 8 Supplement, pp. 305-325, 360-367 (1981).
Lengfelder, E. and Elstner, E. F. (Munich): Determination of the Superoxide Dismutating Activity of D-Penicillamine Copper, Hoppe-Seyler's Z. Physiol. Chem. 359:751-757 (Jun. 1978).
Chou, W. S., Savage, J. E. and O'Dell, B. L. (Columbia, M. O.): Relation of Monoamine Oxidase Activity and Collagen Cross-Linking in Copper-Deficient and Controlled Tissues, Proc. Soc. Exp. Biol. Med. 128:948-952 (Aug.-Sep., 1968).
Scudder, P., Stocks, J. and Dormandy, T. L. (London): The Relationship Between Erythrocyte Superoxide Dismutase and Erythrocyte Copper Levels in Normal Subjects and in Patients with Rheumatoid Arthritis, Clin. Chim. Acta. 69:397-403 (Jun. 15, 1976).
Younes, M. and Weser, U. (Tubingen): Reactivity of Superoxide Dismutase-Active Cu(II) Complexes on the Rate of Adrenochrome Formation, Febs. Lett. 71:87-90 (Nov. 15, 1976).
Joester, K.-E., Jun, G., Weber, U. and Weser, U. (Tubingen): Superoxide Dismutase Activity of Cu.sup.2+ -Amino Acid Chelates, Febs. Lett. 25:25-28, (Sep. 1, 1972).
Lin, P. S., Kwock, L. and Goodchild, N. T. (Boston): Copper Superoxide Radical Diethyldithiocarbamate, and Bleomycin Cytotoxicity (Letter to Edition): Lancet 1:777 (Apr. 7, 1979).
Oberley, J. W., Oberley, T. D. and Buttner, G. R. (Iowa City): Cell Differentiation, Aging in Cancer: The Possible Roles of Superoxide in Superoxide Dismutases. Med. Hypoth: 6:249-268 (Mar. 1980).
Somville, M. and Remacle, J. (Namur): Superoxide Dismutases in Aging Fibroblasts, Arch. Int. Physiol. Biochim. 88:B99-B100 (May, 1980).
Menander-Huber, K. B. and Huber, W. (Mountainview, Calif.): Orgotein, The Drug Version of Bovine Cu-Zn Superoxide Dismutase II. A Summary Account of Clinical Trials in Man and Animals, In: Michaelson, A. N., McCord, J. M. and Friodivich, I. (Eds): Superoxide Dismutases, London: Academic Press, pp. 537-549, (1977).
Gerber, D. A. (New York): Increased Copper Ligand Reactivity in the Urine of Patients with Rheumatoid Arthritis, Arthritis Rheum. 9:795-803 (Dec. 1966).
Sorenson, J. R. J.: The Anti-Inflammatory Activities of Copper Complexes, In: Helmut, S. (Ed.): Metal Ions in Biological Systems, vol. 14, Chp. 4, New York: Marcel Dekker, Inc., pp. 77-124, (1982).
Useful Formulas, In: Martin, E. W. et al (Eds.): Remington's Practice of Pharmacy, 12th Edition, Chp. 99, Easton: Mack Publishing Company, pp. 1802-1803, (1961).
Sorenson, J. R. J.: Therapeutic Uses of Copper, In: Nrigu, J. O. (Ed.): Copper in the Enviroment, Part II, Chp. 5, John Wiley & Sons, Inc., pp. 104-162 (1979).
Walker, W. R. et al.: Anti-Inflammatory Activity of a Dermally Applied Copper Salicylate Preparation (Alcusal.RTM.), Agents and Actons, 10:38-47 (1980).
Walker, W. R. and Reeves, R. R.: Perfusion of Intact Skin by a Saline Solution of Bis-(Blycinato) Copper (II), Bioinorganic Chem. 7:271-276 (1977).
Walker, W. R. and Daphne, M. K.: An Investigation of the Therapeutic Value of the `Copper Bracelet` Dermal Assimilation of Copper in Arthritic/Rheumatoid Condition, Agents and Actions, 6(4):454-459 (1976).
Somville, M. and Remacle, J.: Superoxide Dismutases in Ageing Human Fibroblasts, Societe Bedge de Biochimie, pp. B99-B100 (Dec. 15, 1979).
Dollwet, H. H. A. et al.: Anti-Inflammatory Properties of Copper Implants in the Rat Paw Edema: A Preliminary Study, Agents and Actions, 11:746-749 (1981).
Jackson, G. E. et al.: Metal-Ligand Complexes Involved in Rheumatoid Arthritis-VI, J. Inorg. Nucl. Chem. 40:1227-1234 (1978).
Giuseppe, A. et al: Metal-Ligand Complexes Involved in Rheumatoid Arthritis-V, J. Inorg. Nucl. Chem. 40:1221-1226 (1978).
Beveridge, S. J. et al.: Anti-Inflammatory Activity of Copper Salicylates Applied to Rats Percutaneously in Dimethyl Sulphexide with Glycerol, J. Pharm. Pharmacol. 32:452-427 (1980).
National Research Laboratories
Sneed Helen M. S.
LandOfFree
Methods and compositions for treating inflammation or arthritis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for treating inflammation or arthritis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for treating inflammation or arthritis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1427856