Process for producing interferon

Details Process for producing interferon Process for producing interferon

1984-08-30

1987-07-14

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435811, 424 85, C12P 2100, A61K 4502

Patent

active

046802614

ABSTRACT:
A process for producing interferon comprises culturing interferon-producing mammalian cells in a cell culture medium containing at least one compound selected from the group consisting of ascorbic acid, an ascorbic acid derivative and a vanadium compound. According to the process of the present invention, interferon can be produced in large amounts.

REFERENCES:
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patent: 4144126 (1979-03-01), Burbidge
patent: 4460685 (1984-07-01), Vilcek et al.
Siegel, "Enhancement of Interferon Production by Poly(rI):Poly(rC) in Mouse Cell Cultures by Ascorbic Acid", Nature 254, pp. 531-532 (1975).
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Povolotskii et al, "Effects of Dibazole and Ascorbid Acid on the Antiviral Activity of Human Interferon in Cell Culture", Antibiotiki 24(4), pp. 291-294 (1979) C.A. 91: 32709h.
Dahl, et al, "The Effect of Ascorbic Acid on Production of Human Interferon and the Antiviral Activity in Vitro", Acta Pathol. Microbiol. Scand. Sect B, Microbiol: 84B(5), pp. 280-284 (1976) C.A. 85: 153793.
Blach et al, "Increase in L929 Cell Interferon Production in Serum-Free Medium", Arch. Immunol. Ther. Expl. 30(1-2), pp. 39-41 (1982) C.A. 98:33030m.
Psukas et al, "Kitchen Tricks with Ribonucleoside-Vanadyl Complexes", Federation Proceedings 41(4), p. 1204 Abst. #5452 (1982).
Berger et al, "Characterization of Interferon Massenger RNA Synthesis in Namalva Cells", Journal of Biological Chemistry 255(7), pp. 2955-2961 (1980).
Puskas et al, "Effect of Ribbonucleoside-Vanadyl Complexes on Enzyme Catalysed Reactions Central to Recombinant DNA Technology", Biochemistry 21, pp . 4602-4608 (1982).
Stewart, "The Interferon System", Springer-Verlag, NY (1981) pp. 97-103.
Stewart et al, "Interferons and Their Actions", CRC Press Inc. (1979) pp. 39-46.

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