Process for the preparation of pharmaceutical substance-containi

Details Process for the preparation of pharmaceutical substance-containi Process for the preparation of pharmaceutical substance-containi

1978-07-31

1980-08-19

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

424 19, 424 35, 424258, 424263, 424280, B01J 1302

Patent

active

042183332

ABSTRACT:
A process for the preparation of pharmaceutical substance-containing microcapsules by liquid-liquid phase separation is disclosed. In this process, ethyl cellulose having an ethoxy content of about 48 to about 49.5% by weight is used as a wall-forming agent and polyisobutylene is used as a phase separation inducing agent, and both or either one of the ethyl cellulose and polyisobutylene are used in the form of a mixture of two kinds differing in the average molecular weight.

REFERENCES:
patent: 3155590 (1964-11-01), Miller et al.
patent: 3173878 (1965-03-01), Reyes
patent: 3184386 (1965-05-01), Stephenson
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3623997 (1971-11-01), Powell
patent: 4123382 (1978-10-01), Morse et al.
Merck Index, Eighth Edition, 1968, p. 951.

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