Polycyclic-carbamic acid piperazinoalkyl esters and amides

Details Polycyclic-carbamic acid piperazinoalkyl esters and amides Polycyclic-carbamic acid piperazinoalkyl esters and amides

1989-01-09

1989-11-21

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544357, 544360, 544380, 544393, 544400, C07D40304, C07D24104

Patent

active

048824321

ABSTRACT:
The compounds of the formula: ##STR1## wherein Ad is 1-adamantyl, 2-adamantyl or 3-noradamantyl; X is --O-- or ##STR2## n is 1,2,3 or 4; R.sup.1 and R.sup.2 are, independently, hydrogen, alkyl, phenyl, benzyl, or substituted phenyl or benzyl in which the substituent is alkyl, alkoxy, halo, cyano, nitro or trifluoromethyl; and R.sup.3 is phenyl, benzyl or substituted phenyl or benzyl in which the substituent is alkyl, alkoxy, halo, nitro, cyano or perhalomethyl, 2-, 3-, or 4-pyridinyl, 2-, 4-or 5-pyrimidiny; or 2- or 3-pyrazinyl; R.sup.4 and R.sup.5 are independently, hydrogen, methyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, are useful anxiolytic/antidepressant agents, with elements of antipsychotic activity.

REFERENCES:
patent: 4001223 (1977-01-01), Sugimoto et al.
patent: 4202898 (1980-05-01), Depoortere
patent: 4510140 (1985-04-01), Nardi et al.
patent: 4605655 (1986-08-01), Yevich et al.
Derwent Abstract 85000957/01-German Patent No. 3321-969.
Derwent Abstract No. 87-049798/07-U.S. Pat. No. 4,640,921.
Barone et al., Drug Clin. Pharm., 20,770, 1986.

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