Process for preparing [1S-[1.alpha.,2.alpha.)Z),3.alpha.,4.alpha

Details Process for preparing [1S-[1.alpha.,2.alpha.)Z),3.alpha.,4.alpha Process for preparing [1S-[1.alpha.,2.alpha.)Z),3.alpha.,4.alpha

1990-02-26

1990-12-18

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30700

Patent

active

049787624

ABSTRACT:
A new process for preparing [1S-[1.alpha.,2.alpha.(Z),-3.alpha.,4.alpha.]]-7-[3-[[[ (1-oxoheptyl)amino]acetyl]amino]-methyl]-7-oxabicyclo[2,2,1]hept-2-yl]-5-h eptenoic acid. New intermediates are also described. [1S-(1.alpha.,2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amino ]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid is useful in the treatment of thrombotic disease.

REFERENCES:
patent: 4663336 (1987-05-01), Nakane
patent: 4687865 (1987-08-01), Thottathil
O. Mitsunobu, The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products; Synthesis, 1981, pp. 1-28.
A. Meyers et al., Highly Stereoselective route to (E)-Allyl Amines via Vinyltri-N-Butylphosphonium Salts (Schweizer Reaction); J. Org. Chem., 1981, 46, pp. 3119-3123.
General Acid-Base Catalysis in the Intramolecular Hydrolysis of Phthalamic Acid; J. Am. Chem. Soc., 1957, 79, pp. 1258-1259.

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