Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-05-08
1989-11-21
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514385, 514471, 514443, 514418, 514419, 514415, 514520, 514521, 514522, 514523, 514524, 514525, 514517, 514518, 514319, 514603, 514619, 514649, 514657, A61K 3138, A61K 3134, A61K 3142, A61K 3145
Patent
active
048823520
ABSTRACT:
This invention provides a method for treating the symptoms of schizophrenia which comprises administering to a schizophrenic an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by the general formula: ##STR1## wherein R.sub.1 is selected from the group consisting of organic radicals having fused rings, phenyl, pyridyl ##STR2## X is oxygen or sulfur, Y, if present, is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer between zero and 3. R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consising of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, or ##STR3## R.sub.5 is selected from the group consisting of hydrocarbyl radicals and n is 2 or 3; with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that at least one of R.sub.2, R.sub.3 and R.sub.4 is not H and that R.sub.2 and R.sub.4 are not both OA, except that when R.sub.1 is m-hydroxyphenyl, phenyl or 2-thienyl, the compound is optically-active.
REFERENCES:
patent: 4564628 (1986-01-01), Horn
patent: 4657925 (1987-04-01), Horn
patent: 4722933 (1988-02-01), Horn
Baran Robert J.
Bostich June M.
Nelson Research & Development Co.
Siegel Alan
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