Derivatives of 1-benzyl-2-oxo-5-alkoxy-pyrrolidine, and medicame

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548455, A61K 3140, C07D20727

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active

048823503

ABSTRACT:
Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or metal strain of the formula (I) ##STR1## in which R' represents hydrogen, linear, branched or cyclic alkyl containing up to 12 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical possibly substituted, provided that if R is unsubstituted phenyl, R' does not represent methyl or ethyl; also therapeutic compositions containing those compounds and method of use.

REFERENCES:
patent: 3117975 (1964-01-01), Bortnick et al.
patent: 3132149 (1964-05-01), Bortnick et al.
patent: 3423426 (1969-01-01), Kohn
patent: 3686169 (1972-08-01), Coran et al.
patent: 4138408 (1979-02-01), Mitzlaff
Drugs of the Future, vol. 10, No. 12, 1985, pp. 972, 974.

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