Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-08-12
1989-11-21
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546144, 546145, A61K 3147, C07D40104
Patent
active
048823376
ABSTRACT:
Novel 4-amino-6,7-dimethoxy-2-(6,7-disubstituted-1,2,3,4-tetrahydroisoquinol-2-y l)quinoline compounds have been prepared, including their pharmaceutically acceptable salts and various novel key intermediates therefor. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Preferred compounds include 4-amino-6,7-dimethoxy-2-(6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinol-2 -yl)quinoline and 4-amino-6,7-dimethoxy-2-(7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinol-2 -yl)quinoline. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 4656174 (1987-04-01), Campbell et al.
patent: 4686228 (1987-08-01), Campbell et al.
patent: 4758568 (1988-07-01), Campbell et al.
Campbell, et al., "Chemical Abstracts", vol. 102, 1985, col. 102:45882e.
Ginsburg Paul H.
Hollrah Glennon H.
Pfizer Inc.
Richardson Peter C.
Turnipseed James H.
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