Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Gelling or coagulation
Patent
1997-03-19
1998-12-29
Brock, Michael
Measuring and testing
Liquid analysis or analysis of the suspension of solids in a...
Gelling or coagulation
073 5425, 073 6442, 436 69, 422 73, 435 13, G01N 1100, G01Y 3386, C12Q 156
Patent
active
058544232
ABSTRACT:
The present invention, a thrombo visco-elastogram (TVE), measures the changes in blood elastic and viscous properties in the magnitude and phase of the hydro-dynamic impedance of a tubular blood sample as the thrombus is formed. The present invention is an apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots. An apparatus for practicing the invention includes a tubular conduit connected to a fluid-filled cylindrical chamber and a fluid-filled reservoir, a piezo-electric bender attached to the fluid-filled cylindrical chamber, which creates a volume variation in the fluid-filled cylindrical chamber, a fluid source capable of injecting a fluid into the tubular conduit, a blood source capable of injecting blood into the tubular conduit, and a microprocessor to supply a sinusoidal wave form or limited band frequency content signal to the piezo-electric bender and record and analyze resulting pressure signals. A method for practicing the invention measures the viscosity and elastic shear modulus of a blood sample over time obtaining the average and maximum viscosity and shear modulus for the blood sample as it clots, and further includes applying a forcing signal, which displaces the clotted blood sample, while measuring the applied pressure for clot dislodgement from the walls of the test section. The adherence strength properties of the blood clot are calculated.
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Brock Michael
Politzer Jay L.
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