Human chloride channel

Details Human chloride channel Human chloride channel

1997-01-09

1998-12-29

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 435 6, C07H 2102, C07H 2104, C12Q 168

Patent

active

058544119

ABSTRACT:
The present invention provides a novel human chloride channel (HCCP) and polynucleotides which identify and encode HCCP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCCP and a method for producing HCCP. The invention also provides for agonists, antibodies, or antagonists specifically binding HCCP, and their use, in the prevention and treatment of diseases associated with expression of HCCP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCCP for the treatment of diseases associated with the expression of HCCP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCCP.

REFERENCES:
patent: 5527703 (1996-06-01), Cully et al.
patent: 5543399 (1996-08-01), Riordan et al.
patent: 5559026 (1996-09-01), Price et al.
patent: 5639661 (1997-06-01), Welsh et al.
Greger, R., "Chloride Transport in Thick Ascending Limb, Distal Convolution, and Collecting Duct," Ann. Rev. Physiol., 50:111-112 (1988).
Barnard, E.A., et al., "Molecular biology of the GABA.sub.A receptor: the receptor/channel superfamily," Trends Neurosci., 10(12):502-509 (1987).
Riordan, J.R., et al., "Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA," Science, 245(4922):1066-1073 (1989).
Landry, D., et al., "Molecular Cloning and Characterization of p64, a Chloride Channel Protein from Kidney Microsomes," J. Biol. Chem., 268(20):14948-14955 (1993).
Landry, D.W., et al., "Purification and Reconstitution of Chloride Channels from Kidney and Trachea," Science, 244(4911):1469-1472 (1989).
Redhead, C.R., et al., "A ubiquitous 64-kDa protein is a component of a chloride channel of plasma and intracellular membranes," Proc. Natl. Acad. Sci. USA, 89:3716-3720 (1992).
Liew, C.C., et al., "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags," Proc. Natl. Acad. Sci. USA, 91:10645-10649 (1994).
Fisher et al., Human Molecular Genetics 3(11) : 2053-2059 (1994).
Lorenz et al., Human Molecular Genetics 3(6) : 941-946 (1994).
Hillier et al., GENEBANK accession No. N41765 (24 Jan. 96).
The Pharmacia Catalog (The 1994 Edition) p. 80.
Al-Awqati, "An IAA-Sensitive Vacuolar Chloride Channel," Curr. Top. Membr. (1994), 42(Chloride Channels), 59-72 CODEN: CTMEET; ISSN; 1063-5823.

Affiliated with

Also associated with

Rating

Human chloride channel does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human chloride channel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human chloride channel will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1425989