Treatment to reduce ischemic tissue injury

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 31505

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active

049786687

ABSTRACT:
Intravenous administration of allopurinol, oxypurinol or deferoxamine to a patient suffering a condition of tissue ischemia is effective to reduce damage to affected tissues. The invention has particular application for post-resuscitative treatment of victims of heart attack or stroke.

REFERENCES:
patent: 3624205 (1971-11-01), Hitchings
patent: 3626064 (1971-12-01), Hitchings
patent: 3629410 (1971-12-01), Heifter et al.
patent: 3740433 (1973-06-01), Clody et al.
patent: 4656034 (1987-04-01), Sarnoff
patent: 4661469 (1987-04-01), Sarnoff
Chem. Abst. 97:465h (1982)-Hansson et al.
Chem. Abst. 104:141978(c) (1986)-Bayati et al.
Chem. Abst. 104:161935(q) (1986)-Nordstroem et al.
Chem. Abst. 106: 194.199(m) (1987)-Grum et al.
Chem. Abst. 106: 188.759(p) (1987)-Lee et al.
Chem. Abst. 106: 188708(w) (1987)-Godin et al.
Michael J. Im, Wen-Hui Shen, et al., "Effect of Allopurinol on The Survival of Hyperemic Island Skin Flaps", Div. Plastic Surgery, Dept. Surgery, Johns Hopkins University School of Medicine, Jan. 31, 1983, pp. 276-278.
Kent A. Vasko, Richard A. DeWall, Ann M. Riley, "Effect of Allopurinol in Renal Ischemia", Surgery, May 1972, vol. 71, No. 5, pp. 787-790.
Billy Hammond, Michael Hess, "The Oxygen Free Radical System: Potential Mediator of Myocardial Injury", JACC, vol. 8, No. 1, Jul., 1985, 215-220.
DeWall, Vasko et al., "Responses of the Ischemic Myocardium to Allopurinol", American Heart Journal, Sep., 1971, vol. 82, No. 3, pp. 362-370.
James Stewart et al., "Prevention of Free Radical-Induced Myocardial Reperfusion Injury with Allopurinol", J. Thorac. Cardiovasc. Surg., Jul., 1985, vol. 90, No. 1, pp. 68-72.
Akizuki et al., "Infarct Size Limitation by the Xanthing Oxidase Inhibitor, Allopurinol, in Closed-Chest Dogs with Small Infarcts", Cardiovascular Research, 1985, 19, 686-692.
Myers et al., "Involvement of Hydrogen Peroxide and Hydroxyl Radical in the `Oxygen Paradox`. Reduction of Creatine Kinase Release by Catalase, Allopurinol or Deferoxamine, but not by Superoxide Dismutase", J. Mol. Cell Cardiol. 17, 675, 1985.
Werns et al., "Reduction of the Size of Infarction by Allopurinol in the Ischemic-Reperfused Canine Heart", Circulation, vol. 73, No. 3, Mar., 1986, pp. 518-524.
Koyama et al., "The Role of Oxygen Free Radicals in Mediating the Reperfusion Injury of Cold-Preserved Ischemic Kidneys", Transplantation, vol. 40, No. 6, 1985, pp. 590-595.
Toledo-Pereyra et al., "Effect of Allopurinol on the Preservation of Ischemic Kidneys Perfused with Plasma or Plasma Substitutes", Ann. Surg. 80, pp. 780-782, 1974.
Toledo-Pereyra, et al., "Comparative Effects of Chlorpromazine, Methylprednisolone, and Allopurinol During Small Bowell Preservation", Am. J. Surg., vol. 126, Nov., 1973, pp. 631-634.
Toledo-Pereyra, "Effective Treatment of Severely Damaged Kidneys Prior to Transplantation", Transplantation, No. 16, 1973, pp. 79-80.
Ellen Hale, "The Deadly Side of Unstable Oxyten", Jounal and Courier, May 21, 1986, West Lafayette, Indiana, D1-D3.
Kann et al., "The Development and Use of An Intravenous Preparation of Allopurinol", Am. Journal Med. Sciences, July, 1968, vol. 256, pp. 53-63.
J. McCord, "Oxygen Derived Free Radicals in Postischemic Tissue Injury" reprinted from the New England Journal of Medicine, 1985 pp. 159-162, vol. 312.

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