Dry direct compression compositions for controlled release dosag

Details Dry direct compression compositions for controlled release dosag Dry direct compression compositions for controlled release dosag

1987-11-24

1989-11-21

Kight, John

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, 514777, 514781, 514789, 264123, A61K 920, A61K 922, A61K 926

Patent

active

048821675

ABSTRACT:
The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tablets or implants of biologically active agents. Preferred for producing dry direct compressed products is the combination of: a hydrophobic cellulose derivative; a wax, and, a fatty acid material and/or a neutral lipid since it provides upon dry direct compression a controlled and continuous release tablet or implant of improved structurally integrity against externally imposed forces.

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patent: 4710384 (1987-12-01), Rotman
Jang, Health Food Business, Dec. 1979: 46-47, Controlled Time Release Vitamins and Minerals.

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