Melamine derivatives for use in the treatment of cancer

Details Melamine derivatives for use in the treatment of cancer Melamine derivatives for use in the treatment of cancer

1996-04-02

1998-12-29

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544196, C07D25170, A61K 3153

Patent

active

058542442

ABSTRACT:
The present invention provides compounds of the formula (I) wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH. The compounds are analogs of trimelamol which have comparable activity but enhanced stability, and are useful as anticancer agents, particularly against ovarian cancer.

REFERENCES:
patent: 2420157 (1947-05-01), West
patent: 2476127 (1949-07-01), West
patent: 2476548 (1949-07-01), Hechenbleikner
patent: 2485059 (1949-10-01), Morhman et al.
patent: 2520619 (1950-08-01), Wystrach et al.
patent: 2537131 (1951-01-01), Grossman et al.
patent: 2565194 (1951-08-01), Bacon et al.
patent: 2566225 (1951-08-01), Makay et al.
patent: 2709693 (1955-05-01), Widmer
patent: 2781553 (1957-02-01), Varela et al.
Arnould, R., et al., "Compared cytotoxicity effects of five anticancer drugs on human (HBL) and mouse (B16) melanoma cells in vitro" Chem. Abstract (1991) 114:23 (abstract No. 253q).

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