Compounds and methods for treatment and diagnosis of prostate ca

Details Compounds and methods for treatment and diagnosis of prostate ca Compounds and methods for treatment and diagnosis of prostate ca

1995-08-25

1998-12-29

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530327, 530403, 530412, 5303871, 53038815, 435 691, 435 693, 4352402, 4241851, A61K 3900, A61K 3804, C07K 100, A23J 100

Patent

active

058542060

ABSTRACT:
Compounds and methods for treating and diagnosing prostate cancer are disclosed. The compounds provided include polypeptides that contain at least a portion of a secreted or cell associated prostate cell protein. Such polypeptides may be formulated into vaccines and/or pharmaceutical compositions for immunotherapy of prostate cancer. Alternatively, or in addition, the polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer.

REFERENCES:
patent: 5314996 (1994-05-01), Wright, Jr.
Israeli et al., "Molecular Cloning of a Complementary DNA Encoding a Prostate-specific Membrane Antigen," Cancer Research 53: 227-230, 1993.
H. Lilja et al., Three Predominant Proteins Secreted by the Human Prostate Gland, The Prostate 12, 29-38, 1988.
Peter Christmas et al., Selective Secretion of Annexin 1, a Protein without a Signal Sequence, by the Human Prostate Gland, The Journal of Biological Chemistry 266:4, 2499-2507, 1991.
Majambu Mibikay et al., Molecular Cloning and Sequence of the cDNA for a 94-Amino Acid Seminal Plasma Protein Secreted by the Human Prostate, DNA 6:1, 23-29, 1987.
Lilja and Abrahamsson, "Three Predominant Proteins Secreted by the Human Prostate Gland," Prostate 12:29-38, 1988.
Christmas et al., "Selective Secretion of Annexin 1, a Protein without a Signal Sequence by the Human Prostate Gland," Journal of Biological Chemistry 266(4): 2499-2507, 1991.
Mbikay et al., "Molecular Cloning and Sequence of the cDNA for a 94-Amino-Acid Seminal Plasma Protein Secreted by the Human Prostate," DNA 6(1): 23-29, 1987.

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