Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-01-20
1998-12-29
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C12N 926
Patent
active
058540466
ABSTRACT:
The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP. The invention also provides for the use of substantially purified HHP and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HHP. Additionally, the invention provides for the use of antisense molecules to hhp in pharmaceutical compositions for treatment of diseases associated with the expression of HHP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of hhp. The present invention also relates to anti-HHP antibodies which specifically bind to HHP.
REFERENCES:
Klocker, J. et al., "Combined Application of Cisplatin, Vindesine, Hyaluronidase and Radiation for Treatment of Advance Squamous Cell Carcinoma of the Head and Neck", Am J. Clin Oncol, vol. 18, pp. 425-428.
Laurent, T.C. et al., "Hyaluronan", FASEB J, (1992) vol. 6, pp. 2397-2404.
Lin, Y. et al., "Molecular Cloning of the Human and Monkey Sperm Surface Protein PH-20", Proc. Natl. Acad. Sci. USA, vol. 90, pp. 10071-10075. (GI 585674).
Lin, Y. et al., "A Hyaluronidase Activity of the Sperm Plasma Membrane Protein PH-20 Enables Sperm to Penetrate the Cumulus Cell Layer Surrounding the Egg", J. Cell Biol., (1994) vol. 125, pp. 1157-1163.
Lokeshwar, V.B., et al., "Association of Elevated Levels of Hyaluronidase, a Matrix-Degrading Enzyme, with Prostate Cancer Progression", Cancer Res., 1996, vol. 56, pp. 651-657.
Lu, G. et al., "Sequence Identity and Antigenic Cross-reactivity of White Face Hornet Venom Allergen, Also a Hyaluronidase, with Other Proteins", The Journal of Biological Chemistry, (1995), vol. 270, pp. 4457-4465. (GI 1362656).
Sampson, P.M. et al., "Cytokine regulation of Human Lung Fibroblast Hyaluronan (Hyaluronic Acid) Production", J. Clin Invest, (1992), vol. 90, pp. 1492-1503.
Spruss, T. et al., "Hyaluronidase Significantly Enhaces the Efficacy of Regionalk Vinblastine Checmotherapy of Malignant Melanoma", J Cancer Res Clin Oncol, 1995, vol. 121, pp. 193-202.
Thaler, C.D., "Biochemical Characteriztion of a Glycosylphosphatidylinositol-Linked Hyaluronidase on Mouse Sperm", Biochemistry, vol. 34, pp. 7788-7795. (GI 998338).
Tu, A.T. et al., "Characterization of Lizard Venom Hyaluronidase and Evidence for its Action as a Spreading Factor", Comp Biochem Physiol, 1983, vol. 76, pp. 377-383.
Zhong, S.P. et al., "Biodegradation of Hyaluronic Acid Derivatives by Hyaluronidase", Biomaterials, 1994, vol. 15, pp. 359-365.
Zhu, X. et al., "Sequence Homology Among Sperm Antigens Involed in Mammalian Fertilization: Search for a Common Epitope for Immunocontraception", Arch Androl, 1994, vol. 33, pp. 141-144.
Chen, J., et al., (GI 1209015), GenBank Sequence Database (Accession U09577), National Center for Biotechnology, National Library of Medicine, Bethesda, Maryland, 20894.
Chen et al., (EMBL/GenBank/DDBJ Accession Number U09577, (Mar. 15, 1996), Mar. 15, 1998.
Darnell J, et al. "Molecular Biology of the Cell." Scientific American Books, Inc., NY, pp. 248-257, 1986.
Au-Young Janice
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
LeGuyader John L.
Mohan-Peterson Sheela
Shibuya Mark L.
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