Process for producing trans-4-hydroxy-L-proline

Details Process for producing trans-4-hydroxy-L-proline Process for producing trans-4-hydroxy-L-proline

1996-09-09

1998-12-29

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435107, 4352523, 43525233, 4353201, 536 231, 536 232, C12N 902

Patent

active

058540407

ABSTRACT:
Isolated and purified L-proline-4-hydroxylase which catalyzes hydroxylation of L-proline at the 4-position of L-proline in the presence of 2-ketoglutaric acid and a divalent iron ion to produce trans-4-hydroxy-L-proline. The L-proline-4-hydroxylase may be isolated from a microorganism selected from the group consisting of Dactylosporanlium sp. RHI deposited with the National Institute of Bioscience and Human-Technology Agency of Industrial Science and Technology, Japan, under the designation PERM BP-4400 and Amycolatopsis sp. RH2 deposited as FERM BP-4581.

REFERENCES:
Lawrence et al. "Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis" Biochem. J. 313, 185-191, 1996.
Onishi et al. "Proline hydrixylation by cell free extract of a streptomycete" Biochem. Biophys. Res. Comm. 120, 45-51, Apr. 1984.
Baldwin et al. "Proline 4-hydroxylase: stereochemical course of the reaction" Tetrahedron Lett. 34, 7489-7492, Nov. 1993.

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