Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola

Details Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola

1997-07-17

1998-12-29

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435195, 4353201, 4352523, 435325, 536 232, C12P 2106, C12N 914, C12N 500, C07H 1700

Patent

active

058540237

ABSTRACT:
The invention provides a human S-adenosyl-5-homocysteine hydrolase (SAHH) and polynucleotides which identify and encode SAHH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of SAHH.

REFERENCES:
Goldberg, D.M. and Diamandis, E.P., "Models of Neoplasia and Their Diagnostic Implications: A Historical Perspective" Clin.Chem. (1993) 39:2360-2374.
Gloria, L. et al., "DNA Hypomethylation and Proliferative Activity are Increased in the Rectal Mucosa of Patients with Long-Standing Ulcerative Colitis" Cancer (1996) 78:2300-2306.
Turker, M.S. and Bestor, T.H., "Formation of methylation patterns in the mammalian genome" Mutat.Res. (1997) 386:119-130.
Stryer, L., Biochemistry, W.H. Freeman and Company, San Francisco, CA (1981) p. 612.
Willis, D.B. et al., "Transcription of Methylated Viral DNA by Eukaryotic RNA Polymerase II" Cell Biophys. (1989) 15:97-111.
Bottiglieri, T. And Hyland, K., "S-adenosylmethionine levels in psychiatric and neurological disorders: a review" Acta Neurol.Scand.Suppl. (1994) 154:19-26.
Montgomery, J.A. et al., "Carbocyclic Analogue of 3-Deazaadenosine: A Novel Antiviral Agent Using S-Adenosylhomocysteine Hydrolase as a Pharmacological Target" J.Med.Chem. (1982) 25:626-629.
Newsholme, E.A. and Leech, A.R., Biochemistry for the Medical Sciences, John Wiley & Sons (1983), p. 436.
Palmer, J.L. and Abeles, R.H., "The Mechanism of Action of S-Adenosylhomocysteinase" J.Biol.Chem. (1979) 254:1217-1226.
Coulter-Karis, D.E. and Hershfield, M.S., "Sequence of full length cDNA for human S-adenosylhomocysteine hydrolase" Ann.Hum.Genet. (1989) 53:169-175. (GI 178276; GI 178277).
Bethin, K.E. et al., "Identification of a Major Hepatic Copper Binding Protein as S-Adenosylhomocysteine Hydrolase" J.Biol.Chem. (1995) 270:20698-20702. (GI 904131; GI 904132).
Martin, C.H. et al., "Complete sequence of the bithorax complex of Drosophila" Proc.Natl.Acad.Sci.USA (1995) 92:8398-8402. (GI 969077; GI 969078).
DeLorenzi, M. et al., "Evidence that the abdominal-B r element function is conferred by a trans-regulatory homeoprotein" EMBO J. (1988) 7:3223-3231.
Inagaki, H. et al., "A Large DNA-binding Nuclear Protein with RNA Recognition Motif and Serine/Arginine-rich Domain" J.Biol.Chem. (1996) 271:12525-12531.
Harada, Y. et al., "Complementary DNA Sequence and Chromosomal Localization of xpg, the Mouse Counterpart of Human Repair Gene XPG/ERCC5" Genomics (1995) 28:59-65.
Wnuk, S.F. et al., "Nucleic Acid Related Compounds. 84. Synthesis of 6'-(E and Z)-Halohomovinyl Derivatives of Adenosine, Inactivation of S-adenosyl-L-homocysteine Hydrolase, and Correlation of Anticancer and Antiviral Potencies with Enzyme Inhibition" J.Med.Chem. (1994) 37:3579-3587.
Phadtare, S. et al., "Unsaturated and Carbocyclic Nucleoside Analogues: Synthesis, Antitumor, and Antiviral Activity." J.Med.Chem. (1991) 34:421-429.
Warzocha, K. "2-Chlorodeoxyadenosine Inhibits Activity of Adenosine Deaminase and S-Adenosylhomocysteine Hydrolase in Patients With Chronic Lymphocytic Leukemia" Eur.J.Cancer (1997) 33:170-173.
Coulter-Karis, D.E. and Hershfield, M.S. (GI 178276), GenBank Sequence Database (Accession M61831), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 178277).
Martin, C.H. et al. (GI 969077), GenBank Sequence Database (Accession U31961), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Petrovic, N. et al., (GI 904131), GenBank Sequence Database (Accession L32836), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 904132).
Hohman, R.J. et al., "Purification of S-Adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum: Reversible Inactivation by cAMP and 2'-Deoxyadenosine" Arch.Biochem.Biophy. (1984) 233:785-795.
Hohman, R.J. and Veron, M., "S-Adenosyl-L-homocysteine hydrolase from Dictyostelium discoideum is inactivated by cAMP and reactivated by NAD" FEBS Lett. (1984) 165:265-268. (GI 969077; GI 969078).

Affiliated with

Also associated with

Rating

Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding human S-adenosyl-5-homocysteine hydrola will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1423506