Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-06-11
1998-12-29
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435196, 4352523, 43525411, 4353201, 435325, 435410, 536 232, 935 22, C12N 916, C12N 120, C12Q 168, C07H 2104
Patent
active
058539972
ABSTRACT:
The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.
REFERENCES:
Charbonneau, H. et al., "1002 Protein Phosphatases?", Annu. Rev. Cell Biol., 8: 463-493 (1992).
Wenk, J. et al., "Molecular cloning and primary structure of a protein phosphatase 2C isoform", FEBS Lett., 297: 135-138 (1992).
Terasawa, T. et al., "Molecular Cloning of a Novel Isotype of Mg.sup.2+ -Dependent Protein Phosphatase .beta. (Type 2C.beta.) Enriched in Brain and Heart", Arch. Biochem. Biophys., 307: 342-349 (1993).
Kato, S. et al., "Molecular Cloning and Expression of Mouse Mg.sup.2+ -Dependent Protein Phosphatase .beta.-4 (Type 2C.beta.-4)", Arch. Biochem. Biophys., 318: 387-393 (1995).
Wenk, J., et al., (Direct Submission), GenBank Sequence Database (Accession 247927), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 247927).
Wenk, J., et al., (Direct Submission), GenBank Sequence Database (Accession S90449), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 247926).
Terasawa, T., et al., (Direct Submission), GenBank Sequence Database (Accession 452526), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 452526).
Terasawa, T., et al., (Direct Submission), GenBank Sequence Database (Accession D17411), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 452525).
Bandman Olga
Corley Neil C.
Goli Surya K.
Lal Preeti
Zhang Hong
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Stole Einar
Wax Robert A.
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