Precursors of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benz

Details Precursors of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benz Precursors of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benz

1984-06-25

1986-04-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546170, 546180, C07D21548, C07D21514

Patent

active

045858683

ABSTRACT:
The compounds 5-carboxyl-6-fluoroquinaldine, 6-fluoro-5-methylquinaldine, 6-fluoro-5-methyl-1,2,3,4-tetrahydroquinaldine, 1,2-dihydro-6-fluoro-5-hydroxymethylquinaldine and diethyl 2-[N-(6-fluoro-5-methyl-1,2,3,4-tetrahydroquinaldinyl)]methylenemalonate are disclosed as useful intermediates for preparing the antimicrobial agent 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzol[ij]quinolizine- 2-carboxylic acid.

REFERENCES:
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patent: 4036963 (1977-07-01), Gialdi et al.
patent: 4301288 (1981-11-01), Leir et al.
Acheson, et al. "Add'n Rxs of heterocyclic" CA 82: 154773j, 1975.
Otsuka Pharm. "5 6-Dihalo-2-alkylquinolines" CA 96: 19987f.
Chernuk et al. "Synthesis & properties of . . . " CA 83: 179223p.
Gyul'budagyan, L. V. et al, "2,5-dimethyl-2H, 3 4-dihydrothiopyrano[3,2]-quinolines. CA 87: 167919q.

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