Indolizine derivatives, pharmaceutical compositions and methods

Details Indolizine derivatives, pharmaceutical compositions and methods Indolizine derivatives, pharmaceutical compositions and methods

1977-02-16

1978-07-25

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26029361, 2602948R, 544362, 544127, A61K 3144, C07D22122

Patent

active

041030125

ABSTRACT:
Novel indolizine derivatives of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R.sub.1 and R.sub.2, which are different, represent a hydrogen atom or a group of the formula: ##STR2## wherein R.sub.3 and R.sub.4 which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive.
They are effective for treating certain pathological or otherwise abnormal conditions of the heart and more particularly sinus tachycardia. Certain of them are also useful in the treatment of angina pectoris and cardiac arrhythmia.

REFERENCES:
dainis, Chem. Abstracts, vol. 77, (3), 19,499f, Jul. 17, 1972.
Dainis, Chem. Abstracts, vol. 77, (5), 34,269z, Jul. 31, 1972.
Dainis, Chem. Abstracts, vol. 77, (13), 88,260h, Sep. 25, 1972.
Rosseels et al., Chem. Abstracts, vol. 84, (21), 150,535b, May 24, 1976.

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