Method of preparing hepatitis B core antigen

Details Method of preparing hepatitis B core antigen Method of preparing hepatitis B core antigen

1977-04-20

1978-07-25

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

195 15, A61K 3912, C12K 700

Patent

active

041029968

ABSTRACT:
HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.

REFERENCES:
ling et al., Hepatitis Scientific Memoranda, Jan. 1976, Memo H.
Almeida et al., The Lancet, Dec. 4, 1971, pp. 1225-1227.
Barker et al., J. of Virology, Dec. 1974, pp. 1552-1558.
Fauvel et al., Can. J. Microbiol., vol. 21, (1975), pp. 905-910.
Greenman et al., Vox Sanguinis, vol. 29, (1975), pp. 77-80.
Kaplan et al., J. Virology, vol. 12, No. 5, (1973), pp. 995-1005.
Moritsugu et al., J. of Immunol., vol. 114, Jun. 1975, pp. 1792-1798.
Tsuda et al., J. of Immunol., vol. 115, Sep. 1975, pp. 834-838.

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