Preventing and reversing the formation of advanced glycosylation

Details Preventing and reversing the formation of advanced glycosylation Preventing and reversing the formation of advanced glycosylation

1996-01-18

1998-12-29

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Dentifrices

Oxygen or chlorine releasing compound containing

424 51, 424 52, 424 54, 424 56, 514365, 514367, 548152, 548161, 548164, 548179, 548180, 548190, 548193, 548194, 548202, 548203, 548204, 548205, A61K 3138, C07D27724

Patent

active

058537031

ABSTRACT:
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

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