Steroid total synthesis process utilizing asymmetric induction

Details Steroid total synthesis process utilizing asymmetric induction Steroid total synthesis process utilizing asymmetric induction

1976-12-22

1978-07-25

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603436, 2603458R, 2603459S, 2603477, 2603478, 2603973, 2603974, 260465F, 260465D, 260559R, 2605705C, 260590FA, 260611A, 560103, C07C 9118

Patent

active

041029259

ABSTRACT:
A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

REFERENCES:
lutz et al., "Journal Organic Chemistry", vol. 25, pp. 928-931 (1960).

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