Process for the preparation of pregnane derivatives

Details Process for the preparation of pregnane derivatives Process for the preparation of pregnane derivatives

1977-06-01

1978-07-25

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 500

Patent

active

041029089

ABSTRACT:
A process for the preparation of pregnane derivatives of the formula ##STR1## wherein R.sub.1 is methyl or ethyl and R.sub.2 is methyl, ethyl, formyl, or acetyl, comprises reacting a nitrate ester of the formula ##STR2## wherein R.sub.1 is as above, in the presence of a catalytic amount of a mercury salt of a lower carboxylic acid with formic acid or acetic acid in a dipolar aprotic or basic solvent or with methanol or ethanol in an aprotonic, especially water-miscible, solvent in the presence of a mineral acid.

REFERENCES:
patent: 3741997 (1973-06-01), Berndt et al.
patent: 3764615 (1973-10-01), Hauser
"Organic Reactions in Steroid Chemistry" by Fried et al. (1972).

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