Stereoselective preparation of 3-substituted-4-anilino-piperidin

Details Stereoselective preparation of 3-substituted-4-anilino-piperidin Stereoselective preparation of 3-substituted-4-anilino-piperidin

1989-09-27

1990-12-18

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546194, 546210, 546211, 546213, 546223, 546193, 546244, C07D41706

Patent

active

RE0334952

ABSTRACT:
The present invention is directed to an improved stereoselective tandem substitution and reduction of an imine precursor to the cis form of [3-substituted-4-(phenylamino)piperidine] 3-substituted-4-anilino piperidine compounds or their substituted derivatives.

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D. B. Collum et al., "Substituent Effects on the Stereo-Chemistry, etc", 2/13/84, 4 pages, J. Am. Chem. Soc. 106, (4865-4869O.
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