Pyrrolealdehydes, their preparation and their use

Details Pyrrolealdehydes, their preparation and their use Pyrrolealdehydes, their preparation and their use

1990-02-26

1991-08-27

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548530, A61K 3140, C07D207325

Patent

active

050433482

ABSTRACT:
Pyrrolealdehydes of the formula I ##STR1## wherein R and R.sup.1 independently of one another denote hydrogen or alkyl with 1 to 4 C atoms, R.sup.2 denotes alkyl, which is substituted by acylamino of the formula II ##STR2## wherein X stands for an oxygen or sulphur atom and R.sup.3 denotes hydrogen, optionally substituted alkyl or alkylamino, cycloalkyl with 5 to 7 C atoms, optionally substituted phenyl, an amino group or an optionally substituted phenylamio group, and pharmaceutically acceptable acid addition salts thereof, and wherein R.sup.3 cannot represent hydrogen if R and R.sup.1 denote hydrogen and the pyrrole ring is formylated in the 3-position, their preparation and their use.

REFERENCES:
patent: 3334637 (1967-08-01), Roberts
patent: 3758456 (1973-09-01), Fisher et al.
patent: 3772287 (1973-11-01), Burrows et al.
patent: 4002643 (1977-01-01), Carson
patent: 4008250 (1977-02-01), Bell et al.
patent: 4180660 (1979-12-01), Nudelman et al.
patent: 4701465 (1987-10-01), Tanaka et al.
patent: 4792568 (1988-08-01), Auerbach
C.A. 107:7064k, Geiss et al. (1987).

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