Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-07-23
1991-08-27
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540545, C07D49812, A61K 3155
Patent
active
050433350
ABSTRACT:
The present invention provides 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo [1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione and 9,10,11,12-tetrahydro-2-(tetrahydro-5-methoxy-2-furanyl) -9,12-epoxy-1H-diindolo[1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione process for the preparation thereof, pharmaceutical compositions containing the compounds, and use of the compounds in heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension and inflammatory diseases, allergies, cancer and certain degenerative damage of the central nervous system, as well as diseases of the immune system.
REFERENCES:
patent: 4923986 (1990-05-01), Murakata et al.
Biomedical and Biophysical Research Communications, vol. 135, No. 1, 1986, pp. 297-303; Isolation and Characterization of a Carcinoma-Associated Antigen, A. H. Ross et al.
Heterocycles, vol. 21, No. 1, 1984, pp. 309-324 Natural Product Synthesis via Cycloadditions with N-Sulfinyl Dienophiles, S. M. Weinreb et al.
The Journal of Organic Chemistry, vol. 52, No. 7, 1987 Synthesis of the Aromatic and Monosaccharide Moieties of Staurosporine, R. P. Joyce et al.
Journal of Organic Chemistry, vol. 54, 1989, pp. 824-828 Synthesis of Indolo[2,3-a]Pyrrolo[3,4-c]Carbazoles by Double Fischer Indolizations, J. Bergman et al.
Tetrahedron Letters, vol. 24, No. 13, pp. 1441-1444, 1983 Synthesis of Arcyriaflavin B, I. Hughes et al.
Hartenstein Johannes
Kleinschroth Jurgen
Rudolph Claus
Schachtele Christoph
Anderson Elizabeth M.
Bond Robert T.
Godecke Aktiengesellschaft
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