Alkyl-substituted-tricyclic quinazolinones as bronchodilators

Details Alkyl-substituted-tricyclic quinazolinones as bronchodilators Alkyl-substituted-tricyclic quinazolinones as bronchodilators

1975-02-21

1976-09-21

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602564F, A61K 31505

Patent

active

039820009

ABSTRACT:
The compounds are alkyl-substituted-tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones and pyrimido[2,1-b]quinazolin-6-one, e.g., 2-methyl-2,3-dihydro-10-(4'-fluorobenzyl)-imidazo[2,1-b]quinazolin-5(1OH)- one, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with an alkyl substituted cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole or a 2-organomercapto-3,4,5,6-tetrahydropyrimidine and the cyclization of a 2-(.omega.-hydroxy(branched) alkylamino)-4-quinazolone.

REFERENCES:
patent: 3598823 (1971-08-01), Hardtmann
patent: 3790573 (1974-02-01), Blackburn et al.
patent: 3905976 (1975-09-01), Hardtmann

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