Process for preparing piperidinyl benzimidazoles

Details Process for preparing piperidinyl benzimidazoles Process for preparing piperidinyl benzimidazoles

1991-07-18

1993-01-26

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40106

Patent

active

051823993

ABSTRACT:
The present invention is directed to a new class of piperidinyl benzimidazole antihistamines which can be described by the following formula: ##STR1## wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy and hydrogen; X is represented by hydrogen, COOR.sub.2, in which R.sub.2 is represented by a C.sub.1-4 alkyl, or an alkylene phenyl radical of the formula: ##STR2## wherein T is represented by CHOH, CO, O, or a direct bond; R.sub.1 is represented by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; and the pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
Ohta et al., Chem. Pharm. Bull. (Japan) 34(12), 4916 (1986).
A. Katritzky et al., Comprehensive Heterocyclic Chemistry, vol. 5, Part 4A, Pergamon Press, Oxford, 1984, p. 401.

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