Process for the preparation of N-alkylated quaternary nitrogen c

Details Process for the preparation of N-alkylated quaternary nitrogen c Process for the preparation of N-alkylated quaternary nitrogen c

1990-06-14

1992-05-05

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544408, 544410, C07D24102

Patent

active

051109298

ABSTRACT:
The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10.sup.-5 -10.sup.-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.

REFERENCES:
patent: 3005820 (1961-10-01), Cenker et al.
patent: 3365453 (1968-01-01), Archer
patent: 3749725 (1973-07-01), Freed et al.
patent: 4610984 (1986-09-01), Schonafiger et al.

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