Sulfoxides and sulfones

Details Sulfoxides and sulfones Sulfoxides and sulfones

1974-07-31

1976-09-21

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260328, 424275, 424276, 424277, C07D33512, C07D33908, C07D32708

Patent

active

039818870

ABSTRACT:
Sulfoxides and sulfones of the formula ##SPC1##
Wherein R.sub.1 is COOH, COOR.sub.4, CH.sub.2 OH, or CH.sub.2 OR.sub.5 ; R.sub.2 is CH.sub.3 or C.sub.2 H.sub.5 ; R.sub.3 is H, F, Cl, or Br; R.sub.4 is alkyl of 1-8 carbon atoms; R.sub.5 is alkanoyl of 2-4 carbon atoms; one of the Y groups is SO or SO.sub.2 and the other Y group is CH.sub.2, O, S, SO, or SO.sub.2 ; and the physiologically acceptable salts thereof, which compounds possess anti-inflammatory activity, can be produced by converting in a compound of the formula ##SPC2##
Wherein X is a group convertible into the group --CHR.sub.1 R.sub.2 wherein R.sub.1, R.sub.2, R.sub.3, and Y have the values given above, the group X into the group --CHR.sub.1 R.sub.3.

REFERENCES:
patent: 3639612 (1972-02-01), De Long et al.
Maior, Chem. Abstracts 68: 12922u (1968).
Janczewski et al., Chem. Abstracts 76: 112546h (1972).

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