Psychotropic piperidinylmethyl benzodioxans

Details Psychotropic piperidinylmethyl benzodioxans Psychotropic piperidinylmethyl benzodioxans

1991-06-21

1993-01-26

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546197, C07D40506, A61K 31445

Patent

active

051822920

ABSTRACT:
The compounds ##STR1## in which Z is ##STR2## where R.sup.4 is --H or alkyl; q is one of the integers 0, 1 or 2; Y is H.sub.2 or O; or Z, taken with R.sup.1 forms ##STR3## R.sup.1 is hydrogen or alkyl or combined with Z as described above; R.sup.2 and R.sup.3 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, carbamoyl or sulfonamido or R.sup.2 and R.sup.3, taken together are methylenedioxy, ethylenedioxy or propylenedioxy; m is one of the integers 1, 2 or 3; n is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are antipsychotic, antidepressant and anxiolytic agents useful in relieving the symptoms of these disease states.

REFERENCES:
patent: 4873331 (1989-10-01), Childers et al.
patent: 4882432 (1989-11-01), Abou-Gharbia et al.
patent: 4910302 (1990-03-01), Abou-Gharbia et al.
patent: 4921958 (1990-05-01), Abou-Gharbia et al.
Fozard et al., Br. J. Pharmacol., 90, 273P (1987).

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