Methods and compositions for treating urinary incontinence using

Details Methods and compositions for treating urinary incontinence using Methods and compositions for treating urinary incontinence using

1996-06-28

1998-04-07

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

424449, 424451, 424464, 424310, 424946, A61K 31165, A61K 970, A61K 966, A61K 946

Patent

active

057365776

ABSTRACT:
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin, or a pharmaceutically acceptable salt thereof, substantially free of its R enantiomer. Pharmaceutical compositions comprising (S)-oxybutynin, or a pharmaceutically acceptable salt thereof, substantially free of its R enantiomer, and a pharmaceutically acceptable carrier are also disclosed.

REFERENCES:
Lish et al. "Oxybutynin--A Musculotropic Antispasmodic Drug . . ." Arch. int. Pharmacodyn. 156, 456-488 (1965).
Hock "Clinical Evaluation of Oxybutynin Chloride" Current Therapeutic Research 9, 437-440 (1967).
Fredericks et al. "A Study of the Anticholinergic and Antispasmodic Activity of Oxybutynin . . ." Investigative Urology 12, 317-319 (1975).
Nilvebrant et al. "Dicyclomine, Benzhexol and Oxybutynine Distinguish . . ." Europ. J. Pharmacol. 123, 133-143 (1986).
Tonini et al. "Depressant Action of oxybutynin on the contractility . . ." J. Pharm. Pharmacol. 39, 103-107 (1986).
Kachur et al. "R and S Enantiomers of Oxybutynin: Pharmacological Effects . . ." J. Pharm. Exper. Ther. 247, 867-872 (1988).
Noronha-Blob et al. "Muscarinic Receptors: Relationships Among Phosphoinositude . . ." J. Pharm Exper. Ther. 249, 843-851 (1989).
Noronha-Blob et al. "The Anticholinergic Activity of Agents Indicated for Urinary . . ." J. Pharm. Exper. Ther. 251, 586-593 (1989).
Peterson et al. "In Vivo Crystometrogram Studies in Urethane-Anesthetized and Conscious Guinea Pigs" J. Pharm. Methods 21, 231-241 (1989).
Guarneri et al. "Effects of Oxybutynin, Terodiline, and Nifedipine . . ." Pharm. Research 24, 263-272 (1991).
Noronha-Blob et al. "Enantiomers of Oxybutynin: In Vitro Pharmacological Characterization . . ." J. Pharm. Exp. Ther. 256, 562-567 (1990).
Lowe et al. "Effect of extracellular Ca.sup.2+ on cholinergic, KCl and phorbol ester-mediated . . ." Eur. J. Pharm. 195, 273-279 (1991).
Massad et al. "The Pharmacokinetics of Intravesical and Oral Oxybutynin Chloride" J. Urology 148, 595-597 (1992).
Angelico et al. "In Vivo Effects of Different Antispasmodic Drugs on the Rat Bladder Contractions" J. Pharm. Methods 27, 33-39 (1992).
Guarneri et al. "Effects of Drugs Used in the Therapy of Detrusor Hyperactivity . . ." Pharm. Research 27, 173-187 (1993).
Lindeke et al. "Metabolism of Oxybutynin: establishment of desethyloxybutynin and Oxybutynin N-Oxide formation in Rat Liver Preparations using Deuterium Substitution and Gas Chromatographic Mass Spectrometric Analysis" Biomedical Mass Spectrometry, vol. 8, No. 10, 506-513 (1981).
Kasama et al. "Preparation of Substituted Glycolic acid 4-alkyl-amino-2-butynyl Esters as Antispasmodics and for Regulation of Urination" Chemical Abstracts, vol. 113:23118k, 586 (1990).

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