Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-12-07
1996-03-05
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 9131, 4351721, 4351723, 4352402, 4353201, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 922
Patent
active
054966981
ABSTRACT:
Method for in vivo selection of a ribozyme active at a defined RNA target.
REFERENCES:
Tabler et al. J. Cell. Biochem. Suppl. 15D, 1991, p. 21, CD 215.
Tabler et al. Gene (1991) 108:175-183.
Taylor, et al., "Ribozyme-Mediated Cleavage of an HIV-1 gag RNA: The Effects of Nontargeted Sequences and Secondary Structure on Ribozyme Cleavage Activity", 1 Antisense Res and Dev 173, 1991.
Sambrook, et al., "Molecular Cloning: A Laboratory Manual", published by Cold Spring Harbor Laboratory Press (N.Y.), pp. 7.71-7.78, 1989.
Scanlon et al., "Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein", 88 Proc. Natl. Acad. Sci. 10591, 1991.
Usman et al., "Automated Chemical Synthesis of Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3'-Half Molecule of an Escherichia coli Formylmethionine tRNA", 109 Jrnl of Amer. Chem. Society, 7845, 1987.
Slim et al., "Configurationally Defined Phosphorothioate-Containing Oligoribonucleosides in the Study of the Mechanism of Cleavage of Hammerhead Ribozymes", 19 Nucl Acids Res. 1183, 1991.
Cameron et al., "Specific Gene Expression by Engineered Ribozymes in Monkey Cells", 86, Proc Natl. Acad. Sci. 1939, 1989.
Dropulic, et al., "Functional characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type 1 Expression", 66 Jrnl of Virol. 1432, 1992.
Tsukiyama-Kohara et al., "Internal Ribosome Entry Site Within Hepatitis C Virus RNA", 66 Jrnl of Virol. 1476, 1992.
Perrotta and Been, 31 Biochemistry 16, 1992, "Cleavage of Oligoribonucleosides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence".
Hampel and Tritz, 28 Biochemistry 4929, 1989, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence".
Hampel et al., 18 Nucleic Acids Research 299, 1990, "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA".
Weerasinghe et al., 65 Journal of Virology 5531, 1991, "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme".
Mamone et al., "Design of Hammerhead Ribozymes Targeted by Sequences in HIV, HSV, and the RAT ANF GENE", Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA", Abstract of Keystone, CO (May 27, 1992).
Haseloff and Gerlach, 334 Nature 585, 1988, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities".
Guerrier-Takada et al., 35 Cell 849, 1983, "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme".
Robertson and Joyce, 344 Nature 467, 1990, "Selection In Vitro of an RNA Enzyme that Specifically Cleaves Single-Stranded DNA".
Draper Kenneth G.
Macejak Dennis G.
LeGuyader John L.
Ribozyme Pharmaceuticals Inc.
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