Plaque inhibition with antiplaque oral composition dispensed fro

Details Plaque inhibition with antiplaque oral composition dispensed fro Plaque inhibition with antiplaque oral composition dispensed fro

1994-01-10

1996-03-05

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

424 52, A61K 716, A61K 718

Patent

active

054965403

ABSTRACT:
An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.

REFERENCES:
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patent: 4595613 (1986-06-01), Tavss et al.
patent: 4663152 (1987-05-01), Barth et al.
patent: 4830221 (1989-05-01), Mazzanobile
patent: 5135738 (1992-08-01), Gaffar et al.
patent: 5167951 (1992-12-01), Gaffar et al.
patent: 5279813 (1994-01-01), Gaffar et al.
Becker Deutsche Lebensm.Rundsch. 79(8). 257-266 (1983) PVC limosene etc.
Doege Pharmazie 39(6):423-427 (1984).
Taverna J. Assoc. Off. anal Chem. 73(2):206-210 (1990) PVC limosene etc.

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