Propofol hydrofluorocarbon propellant formulations

Details Propofol hydrofluorocarbon propellant formulations Propofol hydrofluorocarbon propellant formulations

1995-03-23

1996-03-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 514818, 514974, A61K 912

Patent

active

054965373

ABSTRACT:
Non-volatile general anesthetics are advantageously provided to patients in aerosolized form using a metered dose inhaler. The anesthetics are highly lipophilic in character and are rapidly absorbed through the nasal, oral, and lung mucosa. Experiments have shown that propofol is readily soluble in hydrofluorocarbon propellants without the use of surfactants and co-solvents. The solubility allows for the controlled delivery of concentrated pure anesthetic agents like propofol to the airway mucosa of human and animal patients to cause rapid onset of sedation or anesthesia without the requirement of prior intravenous access.

REFERENCES:
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5190029 (1993-03-01), Byron et al.
patent: 5225183 (1993-06-01), Purewal et al.
Kanto, J. H., "Propofol, the newest induction agent of anesthesia" International Journal of Clinical Pharmacology, vol. 26 No. 1 1988 (pp. 41-57).
Gennaro, A. R. (1985). Remington's Pharmaceutical Sciences (17th ed.). Mack Publishing Co., pp. 1670-1677.
More/ n, F. et al. (1993). Aerosols in Medicine. Principles, Diagnosis and Therapy. Elsevier Sci. Publishers, pp. 303-319.
Jakobsson, J. et al. (1995). Acta Anaesthesiologica Scandanavica 39(4): 503-507.

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