Process for chemically removing the acyl sidechain from cephalos

Details Process for chemically removing the acyl sidechain from cephalos Process for chemically removing the acyl sidechain from cephalos

Filed on

1979-07-06

Date issued

1981-02-24

Examiner

Rizzo, Nicholas S.

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Chalcogen in the nitrogen containing substituent

Other Related Categories

548190, 544 27, 544 26, 544 30, 2602452R, C07D50102

Type

Patent

Status

active

Patent number

042529735

Description

ABSTRACT:
A process for removing the acyl sidechain from penicillins and cephalosporins which comprises chlorinating the acyl compound and treating the resulting iminochloride with an o-aminothiophenol to obtain the corresponding 6.beta.-aminopenicillin or 7.beta.-aminocephalosporin.

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patent: 4031087 (1977-06-01), Karady et al.
patent: 4068071 (1978-01-01), Tsushima et al.
patent: 4068072 (1978-01-01), Tsushima et al.
Kardy et al., Tetrahedron Letters, No. 5, pp. 407-408, (1978).
Lunn et al., Tetrahedron Letters, No. 14, pp. 1307-1310, (1974).
Busko-Oszczapowicz et al., Rocznik, Chemii Ann. Soc. Chim. Polonorum, vol. 48, pp. 253-261, (1974).
Shimizu et al., Chem. Phar. Bull., vol. 24, pp. 2629-2636, (1976).
Shiozaki et al., J.C.S. Chem. Comm., pp. 517-518, (1978).

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